Recent Strategies in Design of Antitumor and Antibacterial Fluoroquinolones

Fluoroquinolones are known widely used synthetic antibacterial agents. Generally, there were some obstacles associated with their therapeutic use. Moreover, many research studies all over the world proved variable biological effects of fluoroquinolones such as antituberculosis, anticancer, or even antiviral activities. The current review is focused on modifications that occurred in fluoroquinolone scaffold for repositioning from into anticancer agents especially at C-7 carboxylic C-3 groups. In addition, it includes recent carried out to improve potency, spectrum activity, pharmacokinetics fluoroquinolones. Hence, this may be useful researchers design and synthesis new improved